Upstate South Carolina Vacations from $310
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Your Upstate South Carolina Vacation
With a Upstate South Carolina vacation package, you can forget about the stress of planning and simply focus on experiencing what this thrilling destination has on offer. With so much to do and see on a trip to Upstate South Carolina, it can be hard to know where to begin. Kick off your travels in Greenville at Falls Park on the Reedy and Bon Secours Wellness Arena — two popular attractions here. Another top city worthy of a spot on your itinerary is Spartanburg. Don't miss WestGate Mall and Tyger River Park. Expedia is your one-stop shop for planning your Upstate South Carolina vacation. From hotels and flights, to car rentals and more, we're here to help you create a travel experience like no other.
The Latest Upstate South Carolina vacation packages
Price found within the past 48 hours. Click for updated prices.
Charlotte Marriott City Center
Uptown Charlotte
Save 100% on your flight
Price was $465, price is now $310 per person
$310
per person
Dec 12 - Dec 14
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Charlotte (CLT)
8.8/10 Excellent! (1,001 reviews)
Kind staff, great restaurant
Reviewed on Sep 29, 2025
Hampton Inn Asheville-Tunnel Rd.
Price was $1,028, price is now $583 per person
$583
per person
Nov 16 - Nov 19
found 2 hours ago
Roundtrip non-stop flight included
Philadelphia (PHL) to Asheville (AVL)
9.2/10 Wonderful! (1,008 reviews)
Comfortable and safe. Clean. Easy to reach and convenient parking. One of the elevators was broken but the staff called about it in advance and informed me about it. Will visit again when in the
Reviewed on Sep 29, 2025
Grand Bohemian Lodge Asheville, Autograph Collection®
Biltmore Village
Save 100% on your flight
Price was $897, price is now $522 per person
$522
per person
Dec 6 - Dec 9
found 1 day ago
Roundtrip flight included
New York (NYC) to Asheville (AVL)
9.2/10 Wonderful! (876 reviews)
My husband and I stayed here and wow..what a gorgeous hotel. Our room was very large clean and quiet. We enjoyed the cozy lobby with a cocktail at night and breakfast was very good. We will definitely stay here again! ❤️
Reviewed on Sep 13, 2025
The Westin Charlotte
Uptown Charlotte
Save 100% on your flight
Price was $465, price is now $310 per person
$310
per person
Dec 12 - Dec 14
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Charlotte (CLT)
9/10 Wonderful! (1,003 reviews)
Building had a slight odor
Reviewed on Sep 21, 2025
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See all available trips from Columbus to Upstate South Carolina
View all tripsWhere to stay in Upstate South Carolina
Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville Downtown
3 out of top 10 points of interest in this area
5/5(654 area reviews)
The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.
Discover the most popular places to visit in Upstate South Carolina
Clemson University
5/5(410 reviews)
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy
4.5/5(583 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the great live music or attend a sporting event in this family-friendly area.
Fred W. Symmes Chapel
5/5(12 reviews)
You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.
What to do in Upstate South Carolina
Small-Group Walking Tour in Greenville with Breakfast
$95
per adult
100% of travellers recommend
Epic City Scavenger Hunt in Garden Grove by Operation City Quest
$10
per adult
Upstate South Carolina Hotel Deals
Hilton Greenville
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $114 total per night from Oct 5 to Oct 6
$114 total
Oct 5 - Oct 6
Total with taxes and fees
8/10 Very Good! (1,035 reviews)
"Very nice"
Reviewed on Sep 30, 2025
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd, Greenville, SC
Fully refundable
$95 nightly
The price is $105 total per night from Oct 5 to Oct 6
$105 total
Oct 5 - Oct 6
Total with taxes and fees
8.4/10 Very Good! (1,000 reviews)
Reviewed on Sep 30, 2025
Hyatt Regency Greenville
220 N Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
$166 nightly
The price is $182 total per night from Oct 12 to Oct 13
$182 total
Oct 12 - Oct 13
Total with taxes and fees
8.6/10 Excellent! (1,000 reviews)
"The Hyatt was in the center of eveything that is going on. Staff was very kind and very helpfull and so many good restaurants in walking distance and well night life. Highly recommend staying at the Hyatt Regency!"
Reviewed on Sep 29, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Upstate South Carolina Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Charleston Intl. Airport (CHS) |
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.